%0 Book
%T CD8+ T cell epitopes derived from the polyomavirus capsid protein VP 1
%A Mani, Jiju
%D 2014
%G English
%F 793013402
%O submitted [by] Jiju Mani
%O Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2014
%X One method for treatment of JCV and BKV-related diseases is by adoptive transfer of virus-specific T-cells. Precursor frequency of JCV-capsid protein VP1-specific T-cells was very low compared to other viruses. Optimized assays revealed JCV-specific T cells with high avidity, peptide-specificity and high functional reactivity in long-term cultures. Additionally, novel, naturally processed JCV-VP1-derived CD8+ T cell epitopes were identified. These new data contribute to the development of therapies that, due to their cross-reactivity, target both polyomaviruses-related diseases simultaneously.
%L 610
%9 theses
%9 Text
%9 Hochschulschrift
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0101-6
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0101-6&pdf
%U http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0101-6