%0 Book
%T Design and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosides: new purine isosters as potential drug-like scaffolds
%A Supe, Linda
%D 2014
%G English
%F 791606627
%O vorgelegt von Linda Supe
%O Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2014
%X The work is devoted to study synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones with potential biological activity. 1H-pyrazolo[3,4-b]pyridin-3(2H)-one derived moieties were afforded using classical approaches involving [3+3] cyclocondensation of enamine fragment-containing heterocycle and bielectrophiles, inverse electron-demand Diels-Alder reaction, palladium-catalyzed C-C coupling reaction. N-nucleosides of purine analogues were synthesized using modified silyl Hilbert-Jones method. Scope and limitations of hydrogenation of pyridine ring of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones were studied.
%L 547.593
%9 theses
%9 Text
%9 Hochschulschrift
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0102-2
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0102-2&pdf
%U http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0102-2