%0 Book
%T systems biology approach to understand the influence of SORLA on amyloidogenic processing in Alzheimer's disease
%A Lao, Angelyn
%D 2012
%G English
%F 782499139
%O vorgelegt von Angelyn Lao
%O Enth. Poster
%O Rostock, Univ., Fak. für Informatik und Elektrotechnik, Diss., 2013
%X In this dissertation APP processing is modelled and the influence of SORLA in Alzheimer’s disease is evaluated. A model with both monomeric and dimeric APP in a single compartment best fitted the experimental data suggesting that SORLA prevents APP oligomerization and affects β-secretase indirectly. Including compartmental details into the combined model, the multi-compartmental model determines the relative contribution of SORLA to each APP-cleavage step showing that SORLA specifically impairs the processing of APP dimer and alters the dynamical behavior of beta-secretase.
%L WD 9200
%9 theses
%9 Text
%9 Hochschulschrift
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0075-4
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0075-4&pdf
%U http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0075-4