%0 Book
%T Role of HCN channels in regulation of synaptic plasticity at early postnatal medial perforant path
%A Guli, Xiati
%D 2013
%G English
%F 782236049
%O submitted by : Badel[,] Gulshat (Guli Xiati)
%O Rostock, Univ., Med. Fak., Diss., 2013
%X HCN channel blocker ZD7288 depressed synaptic transmission at medial perforant path (MPP) synapses. Low-frequency stimulation (LFS) delivered to these fibers resulted in enhanced LTD after ZD7288 in P9-15 rats, but not in P30-60 rats. Hence, HCN channel activation during neuronal activity may compromise the propensity of LTD at these synapses. Results obtained with L-NAME iterated the effect of HCN channel inhibition on LTD, suggesting that retrograde signaling with NO might play a major role in the linkage between postsynaptic NMDAR activation and presynaptic HCN channel function.
%L 610
%9 theses
%9 Text
%9 Hochschulschrift
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0064-2
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0064-2&pdf
%U http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0064-2