%0 Book
%T Compartmental modelling of the Wnt pathway: elucidating the role of nucleo-cytoplasmic shuttling of β-catenin and its antagonists
%A Schmitz, Yvonne
%D 2013
%G English
%F 779622480
%O vorgelegt von Yvonne Schmitz
%O Rostock, Univ., Fak. für Informatik und Elektrotechnik, Diss., 2013
%X The Wnt pathway plays a critical role in development and disease. The key player of the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates target gene expression. Its activity is mainly regulated by retention and degradation by its antagonists APC, Axin and GSK3. Based on experimental findings, I develop and investigate compartmental models in order to analyse of the role of nucleo-cytoplasmic shuttling of these proteins in Wnt signalling. I show that the compartmental separation of b-cat and its antagonists yields an increase of the b-cat/TCF concentration.
%L 571.74015118
%9 theses
%9 Text
%9 Hochschulschrift
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0055-2
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0055-2&pdf
%U http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0055-2