%0 Book
%T Spatio-temporal dynamics of the Wnt/β-catenin signaling pathway: a computational systems biology approach
%A Mazemondet, Orianne
%D 2011
%G English
%F 684559005
%O vorgelegt von Orianne Mazemondet
%O Rostock, Univ., Fak. für Informatik und Elektrotechnik, Diss., 2011
%X The Wnt/ß-catenin signaling pathway is involved in human neural progenitor cell differentiation. This dissertation employs the cyclic workflow of computational systems biology to investigate the pathway spatio-temporal dynamics during differentiation. Quantitative in vitro analyses show biphasic kinetics of the pathway proteins. A computational model is developed to investigate in silico these kinetics in correlation with cell cycle and self-induced signaling. We show the importance of stochastic approach and suggest further experiments, hence closing the computational systems biology loop.
%L 610
%9 theses
%9 Text
%9 Hochschulschrift
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2012-0005-4
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2012-0005-4&pdf
%U http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2012-0005-4