%0 Book
%T role of NF-kB and C/EBP factors during pathogen-mediated activation of bovine interleukin 8 and beta-defensin in mammary epithelial cells
%A Liu, Shuzhen
%D 2009
%G English
%F 65676662X
%O by Shuzhen Liu
%O Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2009
%O Langzeitarchivierung gewährleistet pdager
%X Molecular mechanisms of pathogen-induced activation of the IL-8 and LAP genes were investigated in Mammary Epithelial Cells. Activity of the resting IL-8 promoter is inhibited by NF-kappaB p65, but activated quickly after pathogen contact by C/EBP factors. Conversely, NF-kappaB p65 drives LAP expression some time after pathogen induction, while C/EBP factors attenuate activity of this promoter. Hence, in the very same cell type NF-kappaB p65 and C/EBP factors antagonistically regulate both immune relevant genes before and after pathogen mediated stimulation.
%L 636.2089819
%9 theses
%9 Text
%9 Hochschulschrift
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0185-5
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0185-5&pdf
%U http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2009-0185-5
%U http://d-nb.info/101425678X/34
%U http://rosdok.uni-rostock.de/file/rosdok_derivate_000000004087/Dissertation_Liu_2009.pdf