%0 Book
%T Mutation des mitochondrialen ATP8 Gens verbessert den hepatischen Energiestatus im murinen Modell des akuten septischen Leberversagens
%A Hildebrandt, Anke
%D 2009
%G German
%F 63043607X
%O vorgelegt von Anke Hildebrandt
%O Rostock, Univ., Med. Fak., Diss., 2010
%O Online-Ausg.:
%O [Online-Ausg.]
%O Reproduktion 2010 [Online-Ausg.] Online-Ausg.: |2010||||||||||
%O Langzeitarchivierung gewährleistet pdager
%X We investigated whether a mutation in the ATPase subunit-8 gene exerts effects on the course of endotoxemic acute liver failure in mice. Wildtype and ATP8 mutant mice were challenged with D-galactosamine and E. coli lipopolysaccharide and studied 6 hrs thereafter. Induction of endotoxemic liver failure provoked marked liver damage, a drop of total adenosine nucleotide level and an increased malondialdehyde production. In contrast, ATP levels in livers ATP8 mutants remained significantly higher. As a net result, ATP8 mutant mice showed lower transaminase release and better survival rate.
%L 610
%9 theses
%9 Text
%9 Hochschulschrift
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2010-0091-5
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2010-0091-5&pdf
%U http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2010-0091-5
%U http://d-nb.info/1007140712/34
%U http://rosdok.uni-rostock.de/metadata/rosdok_disshab_000000000458