%0 Book
%T Synthesis and catalytic functionalization of biologically active indoles
%A Schwarz, Nicolle
%D 2008
%G English
%F 59268413X
%O vorgelegt von Nicolle Schwarz
%O Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2008
%X Of fundamental importance in nature are substituted indoles. The thesis presents the synthesis of new indole derivatives and their functionalization to potential 5-HT6 receptor ligands. Based on our prior synthesis to indole analogues we investigated a synthetic strategy to innovative indole scaffolds via Ti- or Zn-catalyzed hydrohydrazination of terminal alkynes. We developed the pharmaceutical interesting class of 3-silyloxyindoles and their further application in several catalytic reactions. Buchwald-Hartwig amination, C-O cross- coupling and sulfonylation were utilized and optimized.
%L 540
%9 theses
%9 Text
%9 Hochschulschrift
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0035-0
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0035-0&pdf
%U http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2009-0035-0