%0 Book
%T Establishment of preclinical tumor models for colorectal cancer precision medicine
%A Dai, Meng
%D 2026
%C Germany; Rostock
%C Universität Rostock
%G English
%F 1985138166
%O vorgelegt von Meng Dai
%O GutachterInnen: Annette Zimpfer (Institute of Pathology, Rostock University Medical Center) ; Claudia Maletzki (Department of Medicine, Clinic III-Hematology/Oncology/Palliative Care, Rostock University Medical Center) ; Daniela Aust (Institute of Pathology, University Hospital Carl Gustav Carus)
%O Dissertation Universität Rostock 2026
%X Colorectal cancer (CRC) is the third most prevalent and second deadliest cancer worldwide. This prospective cohort study established patient-derived CRC organoids (75% success rate) and tumor-infiltrating lymphocytes (TILs, 87.5% success rate) as preclinical models for therapy prediction. Targeted NGS sequencing revealed TP53, APC, and KRAS as the most frequent mutations; MSI was detected in 11% of patients. Organoid-TIL co-culture enables exploration of the tumor microenvironment and immune evasion mechanisms, supporting personalized immunotherapy strategies.<eng>
%L 500
%9 theses
%9 Text
%9 Hochschulschrift
%R 10.18453/rosdok_id00005813
%U https://purl.uni-rostock.de/rosdok/id00005813
%U https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00005813-8
%U https://d-nb.info/1420686658/34
%U https://doi.org/10.18453/rosdok_id00005813