%0 Book
%T Metabolic alterations and early development of sarcopenia in a murine model of cholestatic liver disease
%A Agrifoglio, Ottavia
%D 2025
%C Germany; Rostock
%C Universität Rostock
%G English
%F 1981805737
%O vorgelegt von Ottavia Agrifoglio
%O GutachterInnen: Cornelia C. Metges (Research Institute for Farm Animal Biology (FBN), Dummerstorf) ; Robert Jaster (Universitätsmedizin Rostock, Klinik und Poliklinik für Gastroenterologie, Hepatologie und Ernährungsmedizin) ; Ali A. Aghdassi (Universitätsmedizin Greifswald, Klinik und Poliklinik für Innere Medizin A Gastroenterologie, Endokrinologie, Nephrologie, Rheumatologie und Ernährungsmedizin)
%O Dissertation Universität Rostock 2026
%X A murine bile duct ligation (BDL) model was used to study molecular mechanisms of sarcopenia and malnutrition in cholestatic liver disease. C57BL/6J mice randomly underwent a BDL or Sham surgery or were used as controls. Metabolism, inflammatory markers, fractional protein synthesis rate, muscle function and gene expression were assessed. Sarcopenia occurs early, and involves systemic inflammation, a catabolic state, reduced protein synthesis and degradation of muscle proteins. Malnutrition and sarcopenia are present in parallel in, and that they trigger each other in a sort of vicious circle.<eng>
%L 610
%9 theses
%9 Text
%9 Hochschulschrift
%R 10.18453/rosdok_id00005753
%U https://purl.uni-rostock.de/rosdok/id00005753
%U https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00005753-8
%U https://d-nb.info/1416682082/34
%U https://doi.org/10.18453/rosdok_id00005753