%0 Book
%T E2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanoma
%A Dhar, Prabir
%D 2025
%C Germany; Rostock
%C Universität Rostock
%G English
%F 1979689067
%O vorgelegt von Prabir Dhar
%O GutachterInnen: Stefanie Scheu (Universitätsmedizin Rostock, Institut für Immunologie) ; Hugo Murua Escobar (Universitätsmedizin Rostock, Institut für Medizinische Genetik) ; Josef Mautner (Helmholtz Zentrum München, Institut für Virologie)
%O Dissertation Universität Rostock 2026
%X In melanoma, E2F1 plays a key role as a regulator of tumor progression. This study identifies a novel gene regulatory network by which E2F1-induced factor IL6 modulates the melanoma microenvironment by altering CD4+ or CD8+ T cell responses. In neighboring CD4+ and CD8+ T cells, IL6 induced the expression of IL10 as well as changes in the secretome profile. In combination with clinical data from TCGA, this study suggests a new melanoma cancer-specific molecular signature, low-E2F1/high-IL10/low-IL6, which is associated with a favourable clinical outcome.<eng>
%L 570
%9 theses
%9 Text
%9 Hochschulschrift
%R 10.18453/rosdok_id00005667
%U https://purl.uni-rostock.de/rosdok/id00005667
%U https://doi.org/10.18453/rosdok_id00005667