%0 Book
%T Epigenetic studies in bovine mastitis cell models
%A Berthold, Anne
%D 2024
%C Rostock
%C Universität Rostock
%G English
%F 1928914721
%O vorgelegt von Anne Berthold
%O GutachterInnen: Reinhard Schröder (Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät, Institut für Biowissenschaften, Abt. Genetik) ; Christa Kühn (Universität Rostock, Agrar- und Umweltwissenschatliche Fakultät, Abt. Genetik der Krankheitsresistenz) ; Jens Tetens (Georg-August-Universität Göttingen, Department für Nutztierwissenschaften, Abt. Functional Breeding)
%O Dissertation Universität Rostock 2024
%X This study focused on histone modifications and their role in epithelial cell models MAC-T and pbMEC exposed to mastitis pathogens Escherichia coli and Staphylococcus aureus. Main insights were gained by molecular techniques, including N-ChIP-qPCR, RNA-seq, and X-ChIP-seq. Both cell types upregulated immune genes in response to pathogen contact. The findings revealed significantly different gene expression and peaks for H3K4me3 and H3K27me3 between MAC-T and pbMEC. Moreover, the genome-wide data indicated epigenetic control of upregulated genes after the Escherichia coli challenge in pbMEC.<eng>
%L 500
%9 theses
%9 Text
%9 Hochschulschrift
%R 10.18453/rosdok_id00004844
%U https://purl.uni-rostock.de/rosdok/id00004844
%U https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004844-8
%U https://d-nb.info/1370896042/34
%U https://doi.org/10.18453/rosdok_id00004844