%0 Book
%T Assessing the impact of sodium butyrate and a light-activated proton pump on energy metabolism and lifespan of Drosophila melanogaster and Caenorhabditis elegans
%A Müller-Eigner, Annika
%D 2023
%C Rostock
%C Universität Rostock
%G English
%F 1887560912
%O vorgelegt von Annika Müller-Eigner
%O GutachterInnen: Reinhard Schröder (Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät) ; Shahaf Peleg (FBN Dummerstorf) ; Tom Goldammer (FBN Dummerstorf, Agrar- und Umweltwissenschaftliche Fakultät)
%O Dissertation Universität Rostock 2023
%X In this thesis, the impact of sodium butyrate (SB) on mitochondrial and metabolic function and lifespan was investigated. SB treatment showed a rapid and transient increase in oxygen consumption in fly heads. Mass spectrometry analysis revealed incorporation of labeled SB into mitochondrial pathway metabolites. An SB-independent way for mitochondrial activation was assessed in this work. The mitochondrial membrane potential of C. elegans was increased, using a light-activated proton pump, resulting in an extended median lifespan, even if the intervention took part in mid- or late-staged worms.<eng>
%L 500
%9 theses
%9 Text
%9 Hochschulschrift
%R 10.18453/rosdok_id00004576
%U https://purl.uni-rostock.de/rosdok/id00004576
%U https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004576-2
%U https://d-nb.info/1329239512/34
%U https://doi.org/10.18453/rosdok_id00004576