%0 Book
%T Microarray transcriptomics analysis of Hutchinson-Gilford progeria genetic disease and the exploitation of dual RNA-seq technology to unveil host-pathogen interaction
%A Sueto, Salem Oduro Beffi
%D 2023
%C Rostock
%C Universität Rostock
%G English
%F 1877357669
%O vorgelegt von Salem Odura Beffi Sueto
%O GutachterInnen: Georg Fuellen (Institut für Biostatistik und Informatik in Medizin und Alternsforschung, Universität Rostock) ; Michael Walter (Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Rostock) ; Dirk Repsilber (Functional Bioinformatics, Örebro University, Örebro, Sweden)
%O Dissertation Universität Rostock 2023
%X The present work uses transcriptomics data from the microarray platform to study the biological imprint of Hutchinson-Gilford progeria syndrome and other senescence processes such as telomere elongation. Literature review of drug repurposing analysis was conducted to find tools that use transcriptomics data as input. RNA-seq technology was used to simultaneously study the gene expression of both the host (human) and the pathogen (S. pyogenes and Influenza A virus). The host expression was used as input for drug repurposing analysis to identify potential drugs for anti-infective treatment.<eng>
%L 000
%9 theses
%9 Text
%9 Hochschulschrift
%R 10.18453/rosdok_id00004514
%U https://purl.uni-rostock.de/rosdok/id00004514
%U https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004514-9
%U https://d-nb.info/1315379406/34
%U https://doi.org/10.18453/rosdok_id00004514