%0 Book
%T antimicrobial activity of carrier-coupled antisense peptide nucleic acids (PNAs) on streptococci
%A Abt-Becker, Corina
%D 2023
%C Rostock
%C Universität Rostock
%G English
%F 1877132748
%O vorgelegt von Corina Abt-Becker
%O GutachterInnen: Nadja Patenge (Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Universität Rostock) ; Mirko Basen (Institut für Biowissenschaften, Universität Rostock) ; Ulrike Giemsa (Leibniz-Institut für Nutztierbiologie (FBN) Dummerstorf)
%O Dissertation Universität Rostock 2023
%X The pathogens Streptococcus pneumoniae and Streptococcus pyogenes can cause serious diseases. In this work effective carrier-coupled antisense peptide nucleic acids (PNAs) against S. pneumoniae were identified. The counteranion pyrenebutyrate was investigated for its ability to improve uptake of CPP-PNAs in streptococci. Furthermore, transcriptomic effects of CPP-PNA on streptococci were examined. As Galleria mellonella is an increasingly popular infection model organism, additionally the S. pyogenes specific immune response of the larvae was investigated using a proteomics approach.<eng>
%L 500
%9 theses
%9 Text
%9 Hochschulschrift
%R 10.18453/rosdok_id00004509
%U https://purl.uni-rostock.de/rosdok/id00004509
%U https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004509-4
%U https://d-nb.info/131537935X/34
%U https://doi.org/10.18453/rosdok_id00004509