%0 Book
%T Phosphoproteome analysis of the near-haploid cell line HAP1 reveals phosphorylation events originating from PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK)
%A Albony, Hasan
%D 2021
%C Rostock
%C Universität Rostock
%G English
%F 1872125352
%O vorgelegt von Hasan Albony
%O GutachterInnen: Hans-Jürgen Thiesen (Institut für Immunologie, Universität Rostock) ; Christopher Gerner (Fakultät für Chemie, Universität Wien) ; Hugo Murua Escobar (Medizinische Klinik III, Universität Rostock)
%O Dissertation Universität Rostock 2022
%X PBK is a serine/threonine kinase. During mitosis, PBK phosphorylates the inter-zinc finger linker sequence (TGEKP) of hundreds of C2H2 zinc finger proteins and liberates these transcription factors from the condensing chromatin. This study aimed to investigate PBK-dependent phosphorylation events by analyzing the phosphoproteome of both wild and PBK knockout HAP1 cells. The analysis identified candidates belong to DNA- and RNA binding proteins (ADNP and FUBP1) or dynamic regulators of cell organelles (MARCKS and PGRMC1).<eng>
%L 570
%9 theses
%9 Text
%9 Hochschulschrift
%R 10.18453/rosdok_id00004478
%U https://purl.uni-rostock.de/rosdok/id00004478
%U https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004478-9
%U https://d-nb.info/1313002321/34
%U https://doi.org/10.18453/rosdok_id00004478