%0 Book
%T Elucidation of molecular recognition structures of peptides and proteins to antibodies and DNA aptamers by biosensor- mass spectrometry combination
%A Lupu, Loredana-Mirela
%D 2022
%C Rostock
%C Universität Rostock
%G English
%F 1869704800
%O vorgelegt von Loredana-Mirela Lupu
%O Enthält Zeitschriftenartikel
%O GutachterInnen: Markus Tiedge (Institut für Medizinische Biochemie und Molekularbiologie) ; Michael O. Glocker (Universitätsmedizin Rostock und Naturwissenschaftliche Fakultät, Abteilung für Proteomforschung) ; Michael Przybylski (AffyMSLifeChem)
%O Dissertation Universität Rostock 2023 Kumulative Dissertation
%X The PROTEX-SPR-MS method has unveiled several epitopes with promising medical applications, including an epitope peptide suitable for antibody removal in Fabry's disease. Additionally, an epitope conducive to early heart muscle injury diagnosis was identified and characterized.Furthermore, PROTEX-SPR-MS has been employed to study two distinct single-stranded DNA aptamers interacting with a tumor biomarker protein. This analysis has revealed that aptamers have remarkably similar affinity and epitope binding to antibodies, suggesting their potential utility in medical applications.<eng>
%L 500
%9 theses
%9 Text
%9 Hochschulschrift
%R 10.18453/rosdok_id00004458
%U https://purl.uni-rostock.de/rosdok/id00004458
%U https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004458-6
%U https://d-nb.info/1309753776/34
%U https://doi.org/10.18453/rosdok_id00004458