%0 Book
%T Multicellular in vitro systems assessing primary and secondary genotoxicity involved in particle-driven pro-fibrotic conditions
%A Pantzke, Jana
%D 2023
%C Rostock
%C Universität Rostock
%G English
%F 1853934887
%O vorgelegt von Jana Pantzke
%O Enthält Zeitschriftenartikel
%O GutachterInnen: Ralf Zimmermann (Institut für Chemie) ; Hanna Karlsson (Institute of Environmental Medicine)
%O Dissertation Universität Rostock 2023 Kumulative Dissertation
%X Since exposure to inhalable substances such as fibers or fine dusts is associated with the development of pulmonary fibrosis  various in vitro cell models capable of detecting mechanistic changes due to pollutant exposure were developed in this work. Models of different complexity were exposed to particles of various sources and investigated regarding their inflammatory, (secondary) genotoxic and fibrotic potential. The studies have shown that the models are suitable to capture mechanistic processes involved in the development of pulmonary fibrosis and thus facilitate toxicity assessment.<eng>
%L 500
%9 theses
%9 Text
%9 Hochschulschrift
%R 10.18453/rosdok_id00004397
%U http://purl.uni-rostock.de/rosdok/id00004397
%U https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004397-8
%U https://d-nb.info/1298674999/34
%U https://doi.org/10.18453/rosdok_id00004397