%0 Book
%T Modeling perspective on translatability of deep brain stimulation mechanism for treating Parkinsonian motor symptoms in rodent and human
%A Butenko, Konstantin
%D 2021
%C Rostock
%C Universität Rostock
%G English
%F 1799953491
%O vorgelegt von Konstantin Butenko
%O GutachterInnen: Ursula van Rienen (Universität Rostock) ; Rüdiger Köhling (Universitätsmedizin Rostock) ; Madeleine Lowery (University College Dublin)
%O Dissertation Universität Rostock 2022
%X Deep brain stimulation is an established treatment for Parkinson’s disease (PD). However, to advance its effectiveness, researchers need to gain a better understanding of the action mechanism by means of in vivo and in silico studies. This thesis presents neural activation patterns theoretically beneficial for motor improvement in PD and analyzes their theoretical reproducibility in a rat brain. Besides, it elucidates biophysical and computational problems to be addressed in order to optimize animal studies and avoid misconceptions when transferring experimental findings to clinical trials.<eng>
%L 620
%9 theses
%9 Text
%9 Hochschulschrift
%R 10.18453/rosdok_id00003623
%U http://purl.uni-rostock.de/rosdok/id00003623
%U https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00003623-9
%U https://d-nb.info/1293537381/34
%U https://doi.org/10.18453/rosdok_id00003623