%0 Book
%T Immunoglobulin G mediates chemoresistance to oxaliplatin in colon cancer cells by inhibiting the ERK signal transduction pathway
%A Shang, Yuru
%D 2021
%C Rostock
%C Universität Rostock
%G English
%F 1759758876
%O vorgelegt von Yuru Shang
%O GutachterInnen: Dietmar Zechner (Rudolf-Zenker-Institut für Experimentelle Chirurgie, Zentrale Versuchstierhaltung Multimodale Kleintierbildgebung) ; Armin Wiegering (Universitätsklinikum Würzburg, Zentrum Operative Medizin, Klinik und Poliklinik für Allgemein- und Viszeralchirurgie, Gefäß- und Kinderchirurgie) ; Michael Linnebacher (Universitätsmedizin Rostock, Molekulare Onkologie und Immuntherapie, Allgemeine Chirurgie)
%O Dissertation Universität Rostock 2021
%X The aim of this study was to investigate the effect of therapeutically used immunoglobulin G (IgG) on colon cancer in the presence of oxaliplatin. We observed that IgG failed to significantly influence tumor cell viability and tumor growth; however, it significantly inhibited the cytotoxic activity of oxaliplatin in vitro. In addition, we observed that oxaliplatin-induced the activation of ERK; however, IgG inhibits ERK activity. This implies that the application of therapeutical IgG to treating patients, which are receiving oxaliplatin, might have harmful side effects.<eng>
%L 570
%9 theses
%9 Text
%9 Hochschulschrift
%R 10.18453/rosdok_id00003037
%U http://purl.uni-rostock.de/rosdok/id00003037
%U https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00003037-4
%U https://d-nb.info/1293663751/34
%U https://doi.org/10.18453/rosdok_id00003037