%0 Book
%T Effect of cannabidiol on disease-associated functions of human vascular smooth muscle cells: role of the anti-oxidative enzyme heme oxygenase-1
%A Schwartz, Margit
%D 2018
%C Rostock
%C Universität Rostock
%G English
%F 167175865X
%O vorgelegt von Margit Schwartz
%O GutachterInnen: Burkhard Hinz (Universitätsmedizin Rostock, Institut für Pharmakologie und Toxikologie) ; Bernhard Rauch (Universitätsmedizin Greifswald, Institut für Pharmakologie, Abt. Allg. Pharmakologie) ; Karin Kraft (Universitätsmedizin Rostock, Zentrum für Innnere Medizin, Lehrstuhl für Naturheilkunde)
%O Dissertation Universität Rostock 2019
%X Excessive proliferation and migration of VSMC are closely linked to cardiovascular diseases and cancer. The enzyme HO-1 was shown to be involved in anti-proliferative/anti-migratory effects in VSMC. This thesis investigates the effect of CBD on VSMC and HO-1. HO-1 was significantly increased by CBD in an ROS-depentent manner. In addition, inhibition of proliferation and migration of VSMC were observed and not attenuated by inhibition/knockdown of HO-1. This work provides evidence of a CBD-mediated induction of HO-1 in VSMC and potential protective effects  via an HO-1-independent mechanism.<eng>
%L 570
%9 theses
%9 Text
%9 Hochschulschrift
%R 10.18453/rosdok_id00002522
%U http://purl.uni-rostock.de/rosdok/id00002522
%U https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00002522-0
%U https://d-nb.info/1293657557/34
%U https://doi.org/10.18453/rosdok_id00002522