%0 Book
%T Production and characterization of genetically modified magnetized cells for future targeted treatment of cardiovascular diseases
%A Voronina, Natalia
%D 2016
%C Rostock
%C Universität Rostock
%G English
%F 1018502297
%O submitted by Natalia Voronina
%O Dissertation Universität Rostock 2017
%X Gene therapy is a promising tool for cardiovascular disease treatment. Its wide clinical application is, however, limited by the lack of suitable targeted gene delivery systems. In this work, a non-viral vector was tested - composed by polyethyleneimine and magnetic nanoparticles (PEI/MNP) - with primary endothelial cells as in vitro model for angiogenesis and CD133+ hematopoietic stem cells. The obtained results indicate that transient genetic modification of cells with miRNA delivered by PEI/MNP is feasible and results in their magnetization sufficient for targeting and MRI detection.<eng>
%L 610
%9 theses
%9 Text
%9 Hochschulschrift
%R 10.18453/rosdok_id00002056
%U http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2018-0050-4
%U https://nbn-resolving.org/urn:nbn:de:gbv:28-diss2018-0050-4
%U https://d-nb.info/1293652040/34
%U https://doi.org/10.18453/rosdok_id00002056