%0 Book
%T Adhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculation
%A Pügge, Johanna
%D 2016
%C Rostock
%C Universität Rostock
%G English
%F 1009595563
%O vorgelegt von Johanna Pügge
%O Dissertation Universität Rostock 2017
%X Intravital microscopy of the mouse cremaster microcirculation was used to examine the role of specific adhesion molecules in histone-dependent leukocyte recruitment. Histones type 3 were given locally to the cremaster muscle sack and specific adhesion molecules were blocked by systemic administration of monoclonal antibodies. Extracellular histones 3 induced leukocyte recruitment in a dose-dependent manner. Histone-induced neutrophil rolling is predominately mediated by P-selectin/PSGL-1 interactions, whereas histone-induced leukocyte adhesion is inter alia mediated by Mac-1 and LFA-1.<eng>
%L 610
%9 theses
%9 Text
%9 Hochschulschrift
%U http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2017-0168-6