Wnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and Wnt/β-catenin pathway Wnt/[beta]-catenin Talabattula, Venkata Ajay Narendra , 1982- (VerfasserIn) Rolfs, Arndt , 1959- (GutachterIn) Rune, Gabriele M. , 1954- (GutachterIn) Murua Escobar, Hugo (GutachterIn) Universität Rostock (Grad verleihende Institution) Universitätsmedizin Rostock (Grad verleihende Institution) Text theses Text Hochschulschrift 2015 2015 eng electronic resourceremoteComputermedienOnline-Ressource1 Online-Ressource HumanNPCs (hNPCs) are the suitable cell source in translation medicine for neurodegenerative disease. In the present study, effects of Wnt3a on the differentiation of hNPC were studied. The results showed that Wnt3a induces canonical and non canonical Wnt pathways. Furthermore, Wnt3a increases Ca2+ target genes CaMKII and Pyk2 in the differentiating VM cells. The results demonstrated that Pyk2 decreases GSK3β activity and stabilizes β-catenin, suggesting there is an intercross between Wnt/β-catenin and Wnt/Ca2+-pathway via Pyk2.<eng> vorgelegt von Venkata Ajay Narendra Talabattula Dissertation Universität Rostock 2017 610 http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2017-0048-9 Wnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and Wnt/β-catenin pathway--(DE-627)884391353 urn:nbn:de:gbv:28-diss2017-0048-9 oclc: 982657090 ppn: (DE-627)884550958