Magnetic nanoparticle-based gene delivery: mechanisms and clinical perspectives = Magnetische Nanopartikel-basierter Gentransfer : Mechanismen und Klinische Perspektiven Magnetischer Nanopartikel-basierter Gentransfer Magnetische Nanopartikel-basierter Gentransfer: Mechanismen und Klinische Perspektiven Delyagina, Evgenya , 1986- (VerfasserIn) Steinhoff, Gustav , 1958- (GutachterIn) Pützer, Brigitte Maria , 1962- (GutachterIn) Zenke, Martin (GutachterIn) Universität Rostock (Grad verleihende Institution) Universitätsmedizin Rostock (Grad verleihende Institution) Text theses Text Hochschulschrift 2016 2016 eng electronic resourceremoteComputermedienOnline-Ressource1 Online-Ressource The development of safe and efficient gene delivery systems is the key to the overall success of gene therapy. This work introduced a MNP-based nonviral gene delivery approach for transfection in clinically relevant cells. Moreover, the in vitro mechanism studies could explained the beneficial properties of the proposed carrier design. This work demonstrated, that proposed system could efficiently and safely transfect human bone marrow derived mesenchymal stem cells. Additionaly, the clinical perspectives of MNP-based gene therapy were discussed and evaluated in this dissertation.<eng> submitted by Evgenya Delyagina from Reinach BL, Switzerland Dissertation Universität Rostock 2017 610 http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2017-0038-4 Magnetic nanoparticle-based gene delivery--(DE-627)882973460 urn:nbn:de:gbv:28-diss2017-0038-4 oclc: 979376428 ppn: (DE-627)882994220