Exploring the spatio-temporal dynamics of lipid rafts and their role in signal transduction: a modeling and simulation approach Haack, Fiete , 1984- (VerfasserIn) Uhrmacher, Adelinde , 1961- (GutachterIn) Burrage, Kevin (GutachterIn) Klipp, Edda , 1965- (GutachterIn) Universität Rostock (Grad-verleihende Institution) Universität Rostock Fakultät für Informatik und Elektrotechnik (Grad verleihende Institution) Text theses Text Hochschulschrift 2015 2015 eng electronic resourceremoteComputermedienOnline-Ressource1 Online-Ressource The aim of this thesis is to elucidate the biological as well as methodological implications that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the effect of raft-dependent receptors dynamics on both, individual signaling events as well as the canonical Wnt signaling pathway, is thoroughly analyzed. To explore the effect of lipid rafts on individual signaling events, a Cellular-Automata based membrane model is developed. The specific involvement of lipid rafts in Wnt/β-catenin signaling is explored by means of an integrated in silico and in vitro approach.<eng> vorgelegt von: Fiete Haack aus Rostock Dissertation Universität Rostock 2016 004 570 WE 5320 42.15 54.76 42.11 http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2016-0080-1 Exploring the spatio-temporal dynamics of lipid rafts and their role in signal transduction--(DE-627)863005985 urn:nbn:de:gbv:28-diss2016-0080-1 oclc: 956494172 ppn: (DE-627)865456275