Transcriptional responses to radiation exposure facilitate the discovery of biomarkers functioning as radiation biodosimeters Strunz, Sonja , 1981- Text theses Text Hochschulschrift 2013 2013 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource Ill., graph. Darst. The development of new methods for a retrospective quantification of the radiation dose of exposed individuals is of widespread interest. To this end, I developed a computational framework for biomarker discovery and radiation dose prediction and successfully identified gene signatures with which low and medium to high radiation doses can be accurately quantified. To enhance our understanding of the radiation-induced transcriptional response, I additionally analyzed microarray data of human PBLs after ex vivo gamma-irradiation and characterized affected functional processes and pathways. vorgelegt von Sonja Strunz, geb. Boldt Rostock, Univ., Fak. für Informatik u. Elektrotechnik, Diss., 2014 610 WC 7700 44.64 42.11 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0136-2 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0136-2&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0136-2 Transcriptional responses to radiation exposure facilitate the discovery of biomarkers functioning as radiation biodosimeters--(DE-627)793128501 urn:nbn:de:gbv:28-diss2014-0136-2 oclc: 935595132 ppn: (DE-627)796438269