CD8+ T cell epitopes derived from the polyomavirus capsid protein VP 1 CD8-plus Mani, Jiju , 1981- Text theses Text Hochschulschrift 2014 2014 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource Ill., graph. Darst. One method for treatment of JCV and BKV-related diseases is by adoptive transfer of virus-specific T-cells. Precursor frequency of JCV-capsid protein VP1-specific T-cells was very low compared to other viruses. Optimized assays revealed JCV-specific T cells with high avidity, peptide-specificity and high functional reactivity in long-term cultures. Additionally, novel, naturally processed JCV-VP1-derived CD8+ T cell epitopes were identified. These new data contribute to the development of therapies that, due to their cross-reactivity, target both polyomaviruses-related diseases simultaneously. submitted [by] Jiju Mani Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2014 610 44.45 35.76 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0101-6 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0101-6&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0101-6 CD8+ T cell epitopes derived from the polyomavirus capsid protein VP 1--(DE-627)786160616 urn:nbn:de:gbv:28-diss2014-0101-6 oclc: 935558172 ppn: (DE-627)793013402