Design and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosides: new purine isosters as potential drug-like scaffolds Supe, Linda , 1983- Text theses Text Hochschulschrift 2014 2014 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource graph. Darst. The work is devoted to study synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones with potential biological activity. 1H-pyrazolo[3,4-b]pyridin-3(2H)-one derived moieties were afforded using classical approaches involving [3+3] cyclocondensation of enamine fragment-containing heterocycle and bielectrophiles, inverse electron-demand Diels-Alder reaction, palladium-catalyzed C-C coupling reaction. N-nucleosides of purine analogues were synthesized using modified silyl Hilbert-Jones method. Scope and limitations of hydrogenation of pyridine ring of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones were studied. vorgelegt von Linda Supe Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2014 547.593 547.7 540 Organische Chemie http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0102-2 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0102-2&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0102-2 Design and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosides--(DE-627)786793031 urn:nbn:de:gbv:28-diss2014-0102-2 oclc: 935549222 ppn: (DE-627)791606627