A systems biology approach to understand the influence of SORLA on amyloidogenic processing in Alzheimer's disease Lao, Angelyn , 1979- Text theses Text Hochschulschrift 2012 2012 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource Ill., graph. Darst. In this dissertation APP processing is modelled and the influence of SORLA in Alzheimer’s disease is evaluated. A model with both monomeric and dimeric APP in a single compartment best fitted the experimental data suggesting that SORLA prevents APP oligomerization and affects β-secretase indirectly. Including compartmental details into the combined model, the multi-compartmental model determines the relative contribution of SORLA to each APP-cleavage step showing that SORLA specifically impairs the processing of APP dimer and alters the dynamical behavior of beta-secretase. vorgelegt von Angelyn Lao Enth. Poster Rostock, Univ., Fak. für Informatik und Elektrotechnik, Diss., 2013 WD 9200 42.11 44.90 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0075-4 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0075-4&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0075-4 A systems biology approach to understand the influence of SORLA on amyloidogenic processing in Alzheimer's disease--(DE-627)737566647 urn:nbn:de:gbv:28-diss2014-0075-4 oclc: 935384515 ppn: (DE-627)782499139