A systems biology approach to unravel the cellular function of microRNAs Lai, Xin , 1983- Text theses Text Hochschulschrift 2012 [2012] eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource Ill., graph. Darst. The systems biology approach, combining biological data with mathematical modelling, provides the means to elucidate the role of miRNAs in signalling pathways and gene regulatory networks. The approach is characterised by a cyclic process, including biological network construction, mathematical modelling, simulation and experimental validation. Using this approach, I first investigate the regulatory role of miR-34a in a signalling pathway. Second, the investigation of the regulation of a miRNA target hub by multiple and cooperative miRNAs is presented. vorgelegt von Xin Lai Enth. Poster Rostock, Univ., Fak. für Informatik und Elektrotechnik, Diss., 2012 WD 9200 42.11 42.13 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0077-5 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0077-5&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0077-5 A systems biology approach to unravel the cellular function of microRNAs--(DE-627)739804294 urn:nbn:de:gbv:28-diss2014-0077-5 oclc: 935383803 ppn: (DE-627)782487505