Role of HCN channels in regulation of synaptic plasticity at early postnatal medial perforant path Guli, Xiati , 1985- Text theses Text Hochschulschrift 2013 2013 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource Ill., graph. Darst. HCN channel blocker ZD7288 depressed synaptic transmission at medial perforant path (MPP) synapses. Low-frequency stimulation (LFS) delivered to these fibers resulted in enhanced LTD after ZD7288 in P9-15 rats, but not in P30-60 rats. Hence, HCN channel activation during neuronal activity may compromise the propensity of LTD at these synapses. Results obtained with L-NAME iterated the effect of HCN channel inhibition on LTD, suggesting that retrograde signaling with NO might play a major role in the linkage between postsynaptic NMDAR activation and presynaptic HCN channel function. submitted by : Badel[,] Gulshat (Guli Xiati) Rostock, Univ., Med. Fak., Diss., 2013 610 44.37 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0064-2 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0064-2&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0064-2 Role of HCN channels in regulation of synaptic plasticity at early postnatal medial perforant path--(DE-627)779620968 urn:nbn:de:gbv:28-diss2014-0064-2 oclc: 935375118 ppn: (DE-627)782236049