Compartmental modelling of the Wnt pathway: elucidating the role of nucleo-cytoplasmic shuttling of β-catenin and its antagonists [beta]-catenin Schmitz, Yvonne , 1980- Text theses Text Hochschulschrift 2013 2013 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource Ill., graph. Darst. The Wnt pathway plays a critical role in development and disease. The key player of the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates target gene expression. Its activity is mainly regulated by retention and degradation by its antagonists APC, Axin and GSK3. Based on experimental findings, I develop and investigate compartmental models in order to analyse of the role of nucleo-cytoplasmic shuttling of these proteins in Wnt signalling. I show that the compartmental separation of b-cat and its antagonists yields an increase of the b-cat/TCF concentration. vorgelegt von Yvonne Schmitz Rostock, Univ., Fak. für Informatik und Elektrotechnik, Diss., 2013 571.74015118 570 42.15 42.11 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0055-2 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0055-2&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0055-2 Compartmental modelling of the Wnt pathway--(DE-627)778538362 urn:nbn:de:gbv:28-diss2014-0055-2 oclc: 935325012 ppn: (DE-627)779622480