Expression of and immune responses to leukemia antigens in patients with hematological malignancies Casalegno Garduño, Rosaely , 1982- Text theses Text Hochschulschrift 2011 2011 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource graph. Darst. Leukemia cells are characterized by differentially expressed leukemia-associated antigens (LAAs). We wondered whether the expression of the LAAs WT1 and RHAMM as well as the T cellular immune response to these LAAs correlated with the clinical outcome of patients suffering from leukemia. We investigated the expression of WT1 and RHAMM at RNA level using qPCR before and after treatment. We concluded that WT1 is a suitable marker for MRD after allogeneic SCT and that a WT1-specific T cell response might contribute to the maintenance of CR. Rosaely Casalegno Garduño Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2012 610 44.81 44.86 42.13 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2013-0153-1 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2013-0153-1&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2013-0153-1 Expression of and immune responses to leukemia antigens in patients with hematological malignancies--(DE-627)723742987 urn:nbn:de:gbv:28-diss2013-0153-1 oclc: 935175871 ppn: (DE-627)772632693