Patient-individual models of gliomas: establishment, characterization and applications Mullins, Christina Susanne , 1984- Text theses Text Hochschulschrift 2013 2013 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource Ill., graph. Darst. Glioblastomas are the most common and aggressive brain tumors. The aim was establishing tumor models from individual patients (in vitro and in vivo). Modeling was successful from fresh and of note also from vitally frozen patient tumors. The models were characterized in direct comparison to the original tumors. Molecular features as mutations, amplifications and epigenetic alterations were highly maintained. Extensive drug sensitivity screens were performed. These well-defined patient individual models are ideal for establishment of individualized therapies and even immunological strategies. vorgelegt von Christina Susanne Mullins Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2013 44.81 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2013-0132-4 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2013-0132-4&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2013-0132-4 Patient-individual models of gliomas--(DE-627)766723720 urn:nbn:de:gbv:28-diss2013-0132-4 oclc: 935145019 ppn: (DE-627)77007698X