KCNQ channel opening as a powerful mechanism for vasodilation Zhuravleva, Nadezda , 1984- Text theses Text Hochschulschrift 2011 2011 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource Ill., graph. Darst. KCNQ channels were recently found in the vascular system. We have tested the hypothesis that KCNQ channels are powerful targets for relaxation of small systemic and pulmonary arteries. In rat Gracilis arteries we found mRNA expression for KCNQ1, KCNQ3, KCNQ4 and KCNQ5 channels. We found that KCNQ channels mediate vessel relaxation induced by experimental modulators in systemic and pulmonary circulation, in normo- and hypertensive model. Conclusion: KCNQ channels could be powerful targets for vessel relaxation, also in pathological hypertensive conditions. presented by Nadezda Zhuravleva Rostock, Univ., Med. Fak., Diss., 2012 42.17 44.37 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2012-0095-9 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2012-0095-9&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2012-0095-9 KCNQ channel opening as a powerful mechanism for vasodilation--(DE-627)716257807 urn:nbn:de:gbv:28-diss2012-0095-9 oclc: 934849389 ppn: (DE-627)72880977X