Positive stranded RNA viruses: dissecting the capsid of Hepatitis E and Chikungunya viruses Thomas, Saijo , 1979- Text theses Text Hochschulschrift 2010 2010 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource Ill. Capsid protein of two positive stranded RNA viruses, Hepatitis E virus (HEV) and Chikungunya virus (ChikV), were investigated. HEV was detected in swine serum collected in Germany. An infectious system for HEV was established and was used to check its egress. The requirement of various amino acid sequences for the autoproteolytic cleavage of ChikV capsid protease was investigated. I was also able to show that ChikV capsid is recognized by karyopherins and its export is mediated by CRM1 dependent nuclear export signal. vorgelegt von Saijo Thomas Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2011 610 42.30 44.75 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2011-0024-4 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2011-0024-4&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2011-0024-4 Positive stranded RNA viruses--(DE-627)644819502 urn:nbn:de:gbv:28-diss2011-0024-4 oclc: 838905332 ppn: (DE-627)688404820