Novel small molecules as GSK-3β inhibitors in human neural progenitor cells GSK-3[beta] Schmöle, Anne-Caroline , 1983- Text theses Text Hochschulschrift 2010 2010 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource graph. Darst. GSK-3ß as the key enzyme of Wnt/ß-catenin pathway is involved in various processes during the neuronal differentiation of stem and progenitor cells. Therefore small molecules are of great interest as they might provide new pharmacological tools to influence and study underlying mechanism. Thus, we developed a multi-level screening system to identify novel GSK-3ß inhibitors. The influence on Wnt/ß-catenin signaling was evaluated in human neural progenitor cells. New compounds raised the neuronal differentiation, whereat it was shown that the effect was due antagonistic action at GSK-3ß. vorgelegt von Anne-Caroline Schmöle Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2011 44.90 44.37 42.13 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2011-0014-9 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2011-0014-9&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2011-0014-9 Novel small molecules as GSK-3β inhibitors in human neural progenitor cells--(DE-627)655211519 urn:nbn:de:gbv:28-diss2011-0014-9 oclc: 838904981 ppn: (DE-627)68840362X