Spatio-temporal dynamics of the Wnt/β-catenin signaling pathway: a computational systems biology approach Wnt/[beta]-catenin Mazemondet, Orianne , 1981- Text theses Text Hochschulschrift 2011 2011 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource Ill., graph. Darst. The Wnt/ß-catenin signaling pathway is involved in human neural progenitor cell differentiation. This dissertation employs the cyclic workflow of computational systems biology to investigate the pathway spatio-temporal dynamics during differentiation. Quantitative in vitro analyses show biphasic kinetics of the pathway proteins. A computational model is developed to investigate in silico these kinetics in correlation with cell cycle and self-induced signaling. We show the importance of stochastic approach and suggest further experiments, hence closing the computational systems biology loop. vorgelegt von Orianne Mazemondet Rostock, Univ., Fak. für Informatik und Elektrotechnik, Diss., 2011 610 WD 9200 44.90 31.70 42.11 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2012-0005-4 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2012-0005-4&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2012-0005-4 Spatio-temporal dynamics of the Wnt/β-catenin signaling pathway--(DE-627)682491721 urn:nbn:de:gbv:28-diss2012-0005-4 oclc: 838910276 ppn: (DE-627)684559005