The role of NF-kB and C/EBP factors during pathogen-mediated activation of bovine interleukin 8 and beta-defensin in mammary epithelial cells Liu, Shuzhen , 1972- Text theses Text Hochschulschrift 2009 2009 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource Ill., graph. Darst. Molecular mechanisms of pathogen-induced activation of the IL-8 and LAP genes were investigated in Mammary Epithelial Cells. Activity of the resting IL-8 promoter is inhibited by NF-kappaB p65, but activated quickly after pathogen contact by C/EBP factors. Conversely, NF-kappaB p65 drives LAP expression some time after pathogen induction, while C/EBP factors attenuate activity of this promoter. Hence, in the very same cell type NF-kappaB p65 and C/EBP factors antagonistically regulate both immune relevant genes before and after pathogen mediated stimulation. by Shuzhen Liu Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2009 Langzeitarchivierung gewährleistet pdager 636.2089819 630 630 WC 4460 42.63 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0185-5 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0185-5&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2009-0185-5 http://d-nb.info/101425678X/34 http://rosdok.uni-rostock.de/file/rosdok_derivate_000000004087/Dissertation_Liu_2009.pdf The role of NF-kB and C/EBP factors during pathogen-mediated activation of bovine interleukin 8 and beta-defensin in mammary epithelial cells--(DE-627)612922995 urn:nbn:de:gbv:28-diss2009-0185-5 oclc: 837775019 ppn: (DE-627)65676662X