Molecular mechanisms controlling the tissue-specific activity of the nutritionally regulated promoter I of the acetyl-CoA carboxylase-α encoding gene in cattle Shi, Xuanming , 1975- Text theses Text Hochschulschrift 2009 2009 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource Ill., graph. Darst. We analyzed molecular mechanisms controlling the activity of the nutritionally regulated promoter I (PI) of the bovine acetyl-CoA-carboxylase-alpha gene. PI-activity is driven by NF-Y and C/EBP factors having bound to high affinity sites on the proximal PI. However, both factors may also bind to low affinity sites on the distal PI. From there, they act as repressors of PI. We found that NF-Y may diminish and block C/EBP-beta mediated PI activation, even in trans, through direct factor interaction. Alterations in the concentrations of both factors apparently regulate the tissue specific PI-activity. by Xuanming Shi Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2009 Langzeitarchivierung gewährleistet pdager 572.574196422 630 570 630 WC 4460 48.60 42.63 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0184-9 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0184-9&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2009-0184-9 http://d-nb.info/1014260035/34 http://rosdok.uni-rostock.de/file/rosdok_derivate_000000004088/Dissertation_Shi_2009.pdf Molecular mechanisms controlling the tissue-specific activity of the nutritionally regulated promoter I of the acetyl-CoA carboxylase-α encoding gene in cattle--(DE-627)612013553 urn:nbn:de:gbv:28-diss2009-0184-9 oclc: 837774720 ppn: (DE-627)656766433