Spatio-temporal control of Wnt/β-catenin signaling during fate commitment of human neural progenitor cells beta-catenin Bader, Benjamin M. , 1981- Text theses Text Hochschulschrift 2010 2010 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfapplication/pdfOnline-Ressource Ill., graph. Darst. The Wnt/beta-catenin pathway is involved in neural stem cell self-renewal and neuronal differentiation. Further understanding of these processes is a prerequisite of cell replacement therapies in neurodegenerative diseases such as Parkinson's disease. In this context, the role of Wnt/beta-catenin signaling was studied in this thesis which substantiates the presently limited knowledge about neurogenesis in human cell models and shows parallels between the mechanistic knowledge based on rodent models and the use of human neural stem cells for cell replacement strategies in neurodegenerative diseases. vorgelegt von: Benjamin M. Bader Die elektronische Ausgabe weicht von der gedruckten ab. Die gedruckte Ausg. enthält eine CD-ROM mit Videos Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2010 Langzeitarchivierung gewährleistet pdager 570 570 WE 2200 42.15 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2010-0135-6 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2010-0135-6&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2010-0135-6 http://d-nb.info/1010575481/34 http://rosdok.uni-rostock.de/metadata/rosdok_disshab_000000000502 Spatio-temporal control of Wnt/β-catenin signaling during fate commitment of human neural progenitor cells--(DE-627)637185277 urn:nbn:de:gbv:28-diss2010-0135-6 oclc: 838148704 ppn: (DE-627)639568327