Die Mutation des mitochondrialen ATP8 Gens verbessert den hepatischen Energiestatus im murinen Modell des akuten septischen Leberversagens ATP8-Gens Hildebrandt, Anke , 1983- Text theses Text Hochschulschrift 2009 2009 ger electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfapplication/pdfOnline-Ressource Ill., graph. Darst. We investigated whether a mutation in the ATPase subunit-8 gene exerts effects on the course of endotoxemic acute liver failure in mice. Wildtype and ATP8 mutant mice were challenged with D-galactosamine and E. coli lipopolysaccharide and studied 6 hrs thereafter. Induction of endotoxemic liver failure provoked marked liver damage, a drop of total adenosine nucleotide level and an increased malondialdehyde production. In contrast, ATP levels in livers ATP8 mutants remained significantly higher. As a net result, ATP8 mutant mice showed lower transaminase release and better survival rate. vorgelegt von Anke Hildebrandt Rostock, Univ., Med. Fak., Diss., 2010 Online-Ausg.: [Online-Ausg.] Reproduktion 2010 [Online-Ausg.] Online-Ausg.: |2010|||||||||| Langzeitarchivierung gewährleistet pdager 610 610 44.87 42.13 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2010-0091-5 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2010-0091-5&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2010-0091-5 http://d-nb.info/1007140712/34 http://rosdok.uni-rostock.de/metadata/rosdok_disshab_000000000458 Die Mutation des mitochondrialen ATP8 Gens verbessert den hepatischen Energiestatus im murinen Modell des akuten septischen Leberversagens--(DE-627)627686192 urn:nbn:de:gbv:28-diss2010-0091-5 oclc: 669794416 ppn: (DE-627)63043607X