Identification and analysis of functional candidate genes for the inverted teat defect in pigs Tetzlaff, Sylvio , 1977- Text theses Text Hochschulschrift 2009 [2009] eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfapplication/pdfOnline-Ressource Ill., graph. Darst. PTHR1 and LEF1 were analyzed as functional candidate genes for the inverted teat defect in pigs. SNP in both genes could be shown as significantly associated with inverted teats. QTL analyses revealed significant QTL on twelve chromosomes in an experimental and five chromosomes in a commercial pig population. That enabled the information about novel positional candidate genes. Adjacent microarray analyses of epithelial and mesenchymal teat tissues of affected and non-affected animals offered differentially regulated genes. Constitutive quantitative real-time analyses of FGFR2, GHR, HGF, PDGFA, PDGFRA, PDGFB and VEGF revealed significant differential expressions in the compared tissues. vorgelegt von Sylvio Tetzlaff Enth. Beitr. aus versch. Ztschr Rostock, Univ., Math.-Naturwiss. Fak., Diss., 2009 Langzeitarchivierung gewährleistet pdager 636.40896042 630 42.64 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0154-1 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0154-1&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2009-0154-1 http://d-nb.info/1004410840/34 http://rosdok.uni-rostock.de/metadata/rosdok_disshab_000000000298 Identification and analysis of functional candidate genes for the inverted teat defect in pigs--(DE-627)607884185 urn:nbn:de:gbv:28-diss2009-0154-1 oclc: 654438744 ppn: (DE-627)624016218