In vitro and in vivo characterization of neural progenitor cells as putative candidates for experimental studies and clinical trials in cell replacement therapy for neurodegenerative diseases Hovakimyan, Marine , 1977- Text theses Text Hochschulschrift 2008 2008 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource Ill., graph. Darst. Fetal conditionally immortalized striatal cells ST14A and human mesencephalic neural progenitor cells (NPCs) were studied with respect to proliferation and differentiation in in vitro experiments. In in vivo experiments, human NPCs were investigated after transplantation into neonatal and adult hemiparkinsonian rat striatum. The survival, migration and dopaminergic (DAergic) differentiation of human NPCs in the host brain was investigated. Improvement in lesion-induced motor impairment has been demonstrated in both groups of hemiparkinsonian rats, independently from DA-ergic differentiation. vorgelegt von Marine Hovakimyan Enth. 2 Beitr. aus Ztschr Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2009 610 42.63 42.13 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0119-0 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0119-0&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2009-0119-0 In vitro and in vivo characterization of neural progenitor cells as putative candidates for experimental studies and clinical trials in cell replacement therapy for neurodegenerative diseases--(DE-627)603442528 urn:nbn:de:gbv:28-diss2009-0119-0 oclc: 455627820 ppn: (DE-627)604745575