The application of gene expression profiling in the characterization of physiological effects of genetically modified feed components in rats Hartmann, Anja , 1975- Text theses Text Hochschulschrift 2008 2008 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource graph. Darst. The study was conducted to evaluate the adequacy of expression profiling for the characterization of potential physiological side effects of genetically modified (GM) feed components. Feeding experiments with rats fed either GM or non-GM feed components were conducted and a comparative expression profiling, using DNA-chip-technology, was done. As a prerequisite for these expression studies data analysis parameters were optimized. Diet-associated expression differences between the two feeding groups were observed in spleen, small intestine and liver. It was shown that expression profiling provides great sensitivity in monitoring physiological reactions of an organism to such diets. vorgelegt von Anja Hartmann Rostock, Univ., Agrar- u. Umweltwiss. Fak., Diss., 2009 630 630 48.61 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0045-6 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0045-6&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2009-0045-6 The application of gene expression profiling in the characterization of physiological effects of genetically modified feed components in rats--(DE-627)592902536 urn:nbn:de:gbv:28-diss2009-0045-6 oclc: 837022120 ppn: (DE-627)593020790