Synthesis and catalytic functionalization of biologically active indoles Schwarz, Nicolle , 1981- Text theses Text Hochschulschrift 2008 2008 eng electronic resourceremoteComputermedienOnline-Ressourcetext/htmlapplication/pdfOnline-Ressource graph. Darst. Of fundamental importance in nature are substituted indoles. The thesis presents the synthesis of new indole derivatives and their functionalization to potential 5-HT6 receptor ligands. Based on our prior synthesis to indole analogues we investigated a synthetic strategy to innovative indole scaffolds via Ti- or Zn-catalyzed hydrohydrazination of terminal alkynes. We developed the pharmaceutical interesting class of 3-silyloxyindoles and their further application in several catalytic reactions. Buchwald-Hartwig amination, C-O cross- coupling and sulfonylation were utilized and optimized. vorgelegt von Nicolle Schwarz Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2008 540 35.69 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0035-0 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0035-0&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2009-0035-0 Synthesis and catalytic functionalization of biologically active indoles--(DE-627)592166678 urn:nbn:de:gbv:28-diss2009-0035-0 oclc: 370848735 ppn: (DE-627)59268413X