New strategies for the optimisation of N-Acetylneuraminic acid synthesis Zimmermann, Vera , 1979- Text theses Text Hochschulschrift 2008 2008 eng electronic resourceremoteComputermedienOnline-RessourceOnline-Ressource graph. Darst. A model describing the complete enzyme catalysed synthesis of N acetylneuraminic acid (Neu5Ac is presented. The model is expedient to predict the reaction course for various conditions and therefore to calculate reaction times and yields. Using the model, an optimisation of reaction conditions in consideration of different targets was performed. Furthermore, a new method for the purification of Neu5Ac was developed. For the extraction a two step mechanism was assumed. A kinetic model was developed and combined with the model for reaction to simulate the integration of reaction and extraction. Vera Zimmermann Enth. Beitr. aus versch. Ztschr Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2008 660 58.29 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2008-0079-5 http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2008-0079-5&pdf http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2008-0079-5 New strategies for the optimisation of N-Acetylneuraminic acid synthesis--(DE-627)573450099 urn:nbn:de:gbv:28-diss2008-0079-5 oclc: 314777663 ppn: (DE-627)576922498