NAALADL1 as a key modulator of resistance to Tumor Treating Fields therapy in colorectal cancer N-acetylated α-linked Acidic Dipeptidase-like 1 Su, Zhaoran , 1985- (VerfasserIn) Linnebacher, Michael , 1969- (AkademischeR BetreuerIn) Murua Escobar, Hugo Istvan , 1973- (AkademischeR BetreuerIn) Krämer, Oliver Holger , 1971- (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universitätsmedizin Rostock (Grad-verleihende Institution) Text theses Text Hochschulschrift 2025 2025 eng electronic resourceremoteComputermedienOnline-Ressourceapplication/pdf1 Online-Ressource (III, 88 Seiten) Illustrationen, Diagramme Colorectal cancer (CRC) shows heterogeneous responses to Tumor Treating Fields (TTF), a non-invasive therapy disrupting mitosis. In 21 CRC cell lines, TTF induced microtubule disruption, mitotic defects, metabolic stress, DNA damage, and apoptosis. NAALADL1 was upregulated in resistant cells; its knockdown enhanced TTF sensitivity by stabilizing microtubules and inducing G2/M arrest. Virtual screening identified Lumacaftor and Bestatin as synergistic with TTF, highlighting NAALADL1 as a promising target for personalized CRC therapy.<eng> Open Access Urheberrechtsschutz 1.0 vorgelegt von Zhaoran Su GutachterInnen: Michael Linnebacher (Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax-, Gefäß- und Transplantationschirurgie, Universitätsmedizin Rostock) ; Hugo Murua Escobar (Institut und Poliklinik für Medizinische Genetik, Universitätsmedizin Rostock) ; Oliver H. Krämer (Department of Toxicology, Johannes Gutenberg University Mainz) Dissertation Universität Rostock 2026 570 610 616.994 610 https://purl.uni-rostock.de/rosdok/id00005800 https://doi.org/10.18453/rosdok_id00005800 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00005800-2 https://d-nb.info/1420686534/34 NAALADL1 as a key modulator of resistance to Tumor Treating Fields therapy in colorectal cancer--(DE-627)1984316419 urn:nbn:de:gbv:28-rosdok_id00005800-2 doi: 10.18453/rosdok_id00005800 oclc: 1616469054 ppn: (DE-627)1984314068